Oxfendazole Cas:53716-50-0

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INTRODUCE Oxfendazole is a broad spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against roundworm, strongyles and pinworms. Oxfendazole is the sulfoxide metabolite of fenbendazole. Oxfendazole is an anthelmintic (wormer) compound used in veterinary practice. It…
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Description

INTRODUCE

Oxfendazole is a broad spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against roundworm, strongyles and pinworms. Oxfendazole is the sulfoxide metabolite of fenbendazole.
Oxfendazole is an anthelmintic (wormer) compound used in veterinary practice. It comes under the chemical class of the benzimidazoles. This drug is barely used in horses, goats, sheep, and cattle. It is very scarcely applied on dogs and cats. The drug for livestock is majorly available in the form of pills, tablets, drenches, bolus, etc. They are meant for oral consumption. Several drenches are allowed for intraruminal injection in some of the countries. Few countries also prefer injectables and pour-ons. For pet dogs, the drug is available in the form of drenches.

BASIC INFORMATION

Product Name Oxfendazole
Other Name systamex;Methyl [5-(Phenylsulfinyl)benzimidazol-2-yl]carbamate;CFDZ;LODITAC;synanthic;
Cas No. 53716-50-0
Molecular Formula C15H13N3O3S
Molecular Weight 315.3470
Appearance and properties White powder
Storage conditions Stored in normal temperature
Structural Formula 1.53716

Usage:

Oxfendazole is a new broad-spectrum deworming drug, its efficacy is more than twice as high as that of phenylthiobenzimidazole, and the reduction rate is 95-100% for all kinds of gastrointestinal nematodes of sheep, cattle and pigs given at 23.5-5mg/kg dose.The reduction rate of larvae in each stage was 91-98%.It is also effective for taenia brevifolia and nematode, but it is not effective for pig whipworm.This product has low toxicity and good tolerance.The LD50 of mice was above 6400mg/kg.

Production methods

Oxfendazole is prepared from 5-phenylsulfoxide o-phenylenediamine and 1, 3-bis (a rubbed in carbonyl) -S-methiothiourea ring.Yield of 95%.Or by the oxidation of phenylthiobenzole with hydrogen peroxide or peracetic acid.

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