Itraconazole CAS:84625-61-6

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INTRODUCE Itraconazole is a triazole antifungal agent, suitable for patients with fungal infections.The drug is usually given orally or intravenously. BASIC INFORMATION Usage: Itraconazole is used as a broad spectrum of azole antifungal agents, used for systemic infections caused by deep fungi,…

Description

INTRODUCE

Itraconazole is a triazole antifungal agent, suitable for patients with fungal infections.The drug is usually given orally or intravenously.

BASIC INFORMATION

Product Name Itraconazole
Other Name Itraconazole;itraconazole
Cas No. 84625-61-6
Molecular Formula C35H38Cl2N8O4
Molecular Weight 705.63300
Appearance and properties Gray powder
Storage conditions Nomal temperature
Structural Formula 35

Usage:

Itraconazole is used as a broad spectrum of azole antifungal agents, used for systemic infections caused by deep fungi, but also for candidiasis and aspergillosis.

Production methods

Itraconazole was produced by following method.

Compound (I) was obtained from m-dichlorobenzene by a reaction exactly similar to ketoconazole.Compounds (Ⅰ) and 1 – acetyl – 4 – (4 – hydroxy phenyl) piperazine condensation, then water release to acetyl, and of nitrochlorobenzene condensation, hydrogenation reduction, chlorine formate acylation, and then after and hydrazine hydrate reaction, cyclization, alkylation of itraconazole.The intermediate, 1-acetyl-4 -(4-hydroxyphenyl) piperazine, can be prepared from piperazine by the following reaction.

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