Anisole is an aromatic ether with the formula C6H5OCH3.Colorless liquid with fragrance.Soluble in ethanol, ether, insoluble in water.Anisole is prone to electrophilic substitution reaction on the aromatic ring.
Anisole mainly produces p-chloranisole and a small amount of o-chlorine products.2,4, 6-trichloroanisole was obtained by reaction with thionyl chloride.In addition, anisole is heated with hydrobromic acid or hydroiodic acid to break the carbon-oxygen bond, resulting in phenol and halomethane, which are important methods for the determination of methoxy groups on the benzene ring.
Anisole is originally from the distillation of methyl salicylate or methoxybenzoic acid, now mainly by methylation reagent dimethyl sulfate in alkaline aqueous solution and phenol reaction prepared.It can be used as raw materials for organic synthesis, such as synthetic resin, spices, etc.
|Other Name||Methoxybenzene;Anizol;Benzene,methoxy;Anisol;Methyl phenyl ether;|
|Appearance and properties||Colorless Liquid|
|Storage conditions||Store in a normal temperature|
Anisole is used in the production of spices, dyes, medicines, pesticides, also used as solvents.
Anisole was produced by following method.
- It is prepared by the reaction of the methylation agent dimethyl sulfate with phenol in an alkaline solution.The phenol was mixed with sodium hydroxide solution, and dimethyl sulfate was slowly added at 10℃.Gabi was heated to 40℃ for reflux reaction for 18h, and then the oil layer was separated by standing. Anhydrous calcium chloride was dried and then reduced by desorption distillation to obtain anisole.Refining method: Anisole mainly contains impurities such as phenol, aldehyde, peroxide and so on.The phenol can be removed by first washing with the same amount of 10% sodium hydroxide.Rinse with the same amount of water to remove residual sodium hydroxide.The ether layer was dried with calcium chloride and decompressed.If containing aldehydes can be removed by precipitation of nitrophenylhydrazine.Testing and removal of peroxides are the same as for diethyl ether.
2. The mixture of phenol and sodium hydroxide solution, at a certain temperature slowly add dimethyl sulfate reaction is prepared.
3. Add phenol to 13% sodium hydroxide solution, stir until completely dissolved, cool to 10℃, quickly stir, slowly add the theoretical dimethyl sulfate, control the reaction temperature is not more than 30℃, after adding the temperature to 40℃, reflux for 18h.The reaction formula is as follows: after the reaction is finished, cooling, static stratification, take the upper liquid, and wash it with salt water, static stratification, discard the water layer, dry and dehydrate the oil layer with anhydrous calcium chloride, and then decompression distillation, to get the finished product.