2-Chloronicotinic Acid 2942-59-8

Availability: In Stock

CAS NO.: 2942-59-8
M.F.: C6H4ClNO2
M.W: 157.5471

Description

BASIC INFORMATION

Product name 2-chloronicotinic acid
CAS NO. 2942-59-8
M.F. C6H4ClNO2
M.W 157.5471
Structure 1
EINECS 220-937-0
 Chemical Properties
Melting point 176-182°C
Density 1.47 g/cm3
Boiling point 316.8°C
Flash point 118°C
 Safety information
Not dangerous goods.
 Package
Net weight 25KG fiber drum
Gross weight 27.5kg
Package size 380*450mm
Container 11.25ton/20″fcl;  14.5ton/40″FCL

Stability: Stable under normal temperatures and pressures.

Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Quality

Expiry time: 2 years

Specification

Item Standard Test result
Appearance White powder Confirm
Purity NLT99% 99.88%
Water NMT0.5% 0.12%
6-Chloronicotinic acid NMT 0.1% 0.01%
Melting point 176-182°C 178.5°C
Conclusion Up to the standard

USAGE of 2-chloronicotinic acid:

1. The intermediate of the herbicide nicosulfuron and piofluramide.

2. Used as pharmaceutical intermediate, used for manufacturing fuminic acid, fuminic acid, etc.; Pesticide intermediate, used to manufacture nicosulfuron, pifluramide, etc.

Production methods

The preparation methods are as follows.

(1) 3 – methyl pyridine as raw material, the first to react with hydrogen peroxide to generate N – oxygen – 3 – methyl pyridine, and then tied acid agent, in the presence of diisopropyl amine in the solvent and phosphorus oxychloride as the chlorinating agent to ring chloride, 2 – chloro – 5 – methyl pyridine and 2 – chloro – a mixture of 3 – methyl pyridine, crystallization and distillation method of separation technology, can be obtained respectively 2 – chloro – 5 – methyl pyridine and 2 – chloro – 3 – methyl pyridine.Side chain chlorination of 2-chlorine-3-methyl pyridine yields 2-chlorine-3-trichloromethyl pyridine, and further hydrolysis yields 2-chloro-3-pyridine formyl chloride or 2-chloro-3-pyridine carboxylic acid (2-chloro-niacin).

(2) Chlorine is injected into the mixture of phosphorus oxychloride and phosphorus trichloride, and the temperature is controlled at about 60℃. Until the remaining chlorine gas escapes, cool it and add n-oxide niacin in batches to heat the mixture.The reaction took place at 100 ~ 105℃ for 1 ~ 1.5h. After the reaction mixture was transparent, the reaction was stirred for 30min, and the phosphorus trichloride was removed under pressure. The residue was cooled to room temperature, and the finished product was prepared by adding water.

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